Detection and response to acute systemic hypoxia
نویسندگان
چکیده
منابع مشابه
Mast cells mediate the microvascular inflammatory response to systemic hypoxia.
Systemic hypoxia produces an inflammatory response characterized by increases in reactive O(2) species (ROS), venular leukocyte-endothelial adherence and emigration, and vascular permeability. Inflammation is typically initiated by mediators released from activated perivascular cells that generate the chemotactic gradient responsible for extravascular leukocyte accumulation. These experiments w...
متن کاملHypercholesterolemia blunts forearm vasorelaxation and enhances the pressor response during acute systemic hypoxia.
OBJECTIVE During hypoxia, active substances released by the endothelium play a key role in the cardiovascular and respiratory responses elicited to optimize oxygen delivery. As hypercholesterolemia is a major cause of endothelial dysfunction, it may interfere with these responses. METHODS AND RESULTS We studied cardiovascular and ventilatory responses to acute systemic hypoxia in 14 patients ...
متن کاملChemoreceptors and cardiovascular control in acute and chronic systemic hypoxia.
This review describes the ways in which the primary bradycardia and peripheral vasoconstriction evoked by selective stimulation of peripheral chemoreceptors can be modified by the secondary effects of a chemoreceptor-induced increase in ventilation. The evidence that strong stimulation of peripheral chemoreceptors can evoke the behavioural and cardiovascular components of the alerting or defenc...
متن کاملAdenosine and muscle vasodilatation in acute systemic hypoxia.
Adenosine is released by skeletal and cardiac muscles when their metabolism increases: it serves to couple O2 supply with O2 demand by causing vasodilatation. This review argues that adenosine plays a similar role in skeletal muscle in systemic hypoxia. It accounts for approximately 50% of the increase in muscle vascular conductance and, within muscle, it causes dilatation of individual arterio...
متن کاملCerebral blood flow response to acute hypoxic hypoxia
Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF) maintaining oxygen delivery to the brain. However, this response, particularly at the tissue level, is not well characterised. This study quantifies the CBF response to acute hypoxic hypoxia in healthy subjects. A 20-min hypoxic (mean P(ETO2) = 52 mmHg) challenge was induced and controlled by dynamic end-t...
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ژورنال
عنوان ژورنال: BJA Education
سال: 2020
ISSN: 2058-5349
DOI: 10.1016/j.bjae.2019.10.004